An example of something refractory is a material like silica or alumina that are difficult to melt. Primary central nervous system lymphoma, for relapsed or refractory disease or induction therapy 7. Some diseases are acute, producing severe symptoms that terminate after a short time, e. Higher risk myeloma multiple myeloma survival rate. Here, the authors address the management of functional dyspepsia and non erosive reflux disease that. Extrapolation from randomised controlled trial and some reallife data suggest. Some patients never respond to a glutenfree diet, others initially responded but have a recurrence of symptoms and intestinal inflammation. The diagnostic and statistical manual of mental disorders dsm, the widely used psychiatric. Refractory inflammatory bowel disease ibd can be defined as persistent acute symptomatic disease despite antiinflammatory therapy or as chronically active disease requiring continuous treatment for relief of symptoms. The oxford english dictionary defines refractory, as it relates to. Refractory gout may not go away with standard treatments.
High risk multiple myeloma represents about 15% of all myeloma cases, however it has historically had a life expectancy that is one half of that for low risk disease. Original article mediumterm results of oral tacrolimus treatment in refractory in. Twentyone patients were treated with 38 cycles ofrituximab. Opportunities and forecast 20142024 report has been added to s offering. We are reporting our observation on patients characteristics. Refractory or resistant hypertension townsend 2002 the. Refractoriness can be mitigated by tight monitoring and early use of both synthetic and.
The global high temperature refractory insulation material market. Refractory definition of refractory by medical dictionary. Pr could have been achieved at some point, but the recipient is no longer in pr. Standard treatment guidelines and essential medicines list. A potential role for viral infections has been implicated in inflammatory bowel disease ibd unresponsive to medical treatment. An abnormal condition of a part, organ, or system of an organism resulting from various causes, such as infection, inflammation, environmental. Mar 19, 2019 since refractory disease may be due to individual differences in pathophysiology, the use of tumor and other biomarkers will help predict or diagnose the occurrence of the tumor, its prognosis and. Jan 10, 2021 the disease is associated with significant morbidity and mortality. The guideline covers chapters of common diseases in tanzania. Find out which words work together and produce more natural sounding english with the oxford collocations dictionary app. In medicine, describes a disease or condition that does not respond to treatment. Pdf to summarize and discuss the conceptual and operational.
The definition of refractory is stubborn or hard to manage, or heat resistant. Some patients never respond to a glutenfree diet, others initially responded but have a recurrence of symptoms and. Introduction gastroesophageal reflux disease gerd is a common gastrointestinal gi disorder worldwide. Early stages of this cancer is asymptomatic, meaning that it can run an indolent course. A refractory disease is a disease that resists treatment. Defining refractory rheumatoid arthritis annals of the. Feb 01, 1997 antitumornecrosisfactor antibody ca2 induced remission in 8 of 10 patients with refractory crohns disease after a single intravenous infusion. If you do not find an acronym or abbreviation, or a definition that you. A morbid entity ordinarily characterized by two or more of the following criteria. A fortyfouryearold woman selfpresented with malaise and dyspnoea. Disease definition of disease by the free dictionary. Refractory definition, hard or impossible to manage.
Refractory coeliac disease type 2 is a rare subtype of coeliac disease with high mortality rates. Treatment options include azathioprine aza, 6mercaptopurine 6mp, methotre. Sandhoffs disease an autosomal recessive inherited disease similar to taysachs disease with the same signs, but differing in that both the enzymes hexosaminidase a and b are defective and it develops more rapidly and can be found among the general population. I hope you like this disease dictionary application. Refractory disease article about refractory disease by the. For specific diseases, see under the specific name, as addisons disease. Advanced treatment if refractoryresistant to treatment or patient has systemic. The meaning of refractory cancer is cancer that fails to respond to. Refractory disease definition of refractory disease by the.
It is well known that epsteinbarr virus ebv infection can elicit a brisk mononuclear response in the gastrointestinal tract. Classification and management of refractory coeliac disease. There is limited data on treatment, management of refractory and relapsed disease, and longterm outcome. Interleukin10 il10 was administered as an enema to 3 patients with refractory ulcerative colitis and there was improvement in symptoms and in the endoscopic appearance of the mucosa. Mental disability or disease which fails to respond to treatment, remaining problematic to cure. Refractory disease nondestructive periodontal disease patient who, when monitoring over time of exhibits, additional losses attachments in one or more sites. Analysis by material ceramic fibers, insulating fire bricks, calcium silicate, end user, by region, by country 2019 edition.
Refractory disease synonyms, refractory disease pronunciation, refractory disease translation, english dictionary definition of refractory disease. They are typically composed of oxides or non oxides like carbides, nitrides etc. Refractory disease nondestructive periodontal disease patient who, when monitoring over time of exhibits, additional losses attachments in one or more sites, despite repeated professional periodontal therapy and the patient who practice satisfactory selfhelp and should be recommended program of periodontal maintenance visits box 152. Patients who have a normal endoscopy account for approximately 90% of all patients with refractory gerd22, which makes testing for gerd. Treatment of relapsed or refractory classical hodgkin lymphoma with. Highlights refractory disease is defined as failure to attain a predefined target, which is now accepted to be remission or, at least, a low disease activity state. Recurrences of the disease new signs and symptoms destructive periodontal disease, which occur after periodontal treatment, because the disease was not adequate treatment andor the patient was not the practice of proper care 2. To evaluate how the clinical and sociodemographic findings of the mm patient with symptomatic relapse andor refractory disease can affect the selection of treatment after the latest symptomatic relapse andor refractory episode.
Apr 28, 20 psychology definition of refractory mental illness. Definitions of refractory ra thus far have been arbitrary, and outcome data and impact of such cohorts remain limited. Unresponsive to stimuli, as a muscle or nerve fiber. Oncology 101 dictionary association of community cancer. Almost an equal percentage of patients with pva 55% and tva 56% had a complete clinical response. An empiric course of ppi therapy is an effective and costeffective strategy for the management of gerd. Subclinical disease also called silent disease, silent stage, or asymptomatic disease. Adverse events aes were coded using the medical dictionary for. Refractory functional dyspepsia and nonerosive reflux disease. We use cookies to enhance your experience on our website, including to provide targeted advertising and track usage. Despite the enthusiastic progresses in the field of rheumatoid arthritis pharmacotherapy, few patients are still reaching sustained remission. Nonrefractory meaning best 1 definitions of nonrefractory. Clinically, refractory cancer is identified if the disease fails to respond or. Longterm data and randomised comparison studies, however, are required before incorporating endoscopic therapies in the management algorithm for refractory gerd.
A condition or tendency, as of society, regarded as abnormal and harmful. Nci dictionary of cancer terms national cancer institute. Dictionary thesaurus, legal, encyclopedia, wikipedia 0. Definition of refractory adjective in oxford advanced learners dictionary. Mar 29, 2021 read medical definition of refractory. Disease status just prior to the start of the preparative regimen for hematopoietic stem cell transplantation hsct. Apr 01, 2021 background nodular lymphocytepredominant hodgkin lymphoma nlphl is an uncommon variant of hodgkin lymphoma. Polatuzumab vedotin, bendamustine, and rituximab for the. The increasing number of patients with persistent symptoms on acid suppressive therapy presents a. Gastroesophageal reflux disease gerd is a common disorder that is treated with lifestyle modification, weight loss, and medications, such as proton pump inhibitors ppis. We in hospital seri manjung have been successful in tackling cases of kawasaki disease thanks in large to these guidelines. Youll find a free pdf healthcare guide to help you get the most out of your personal medical care. Refractory definition of refractory by merriamwebster.
Treatment of refractory gastroesophageal reflux disease. Some metals with melting points 1850 c like niobium. Advanced treatment if refractory resistant to treatment or patient has systemic. This article focuses on recognizing refractory gerd and refractory symptoms of gerd, the differential diagnosis, and the role of diagnostic testing and therapeutic options. Pdf mediumterm results of oral tacrolimus treatment in. Refractory definition is resisting control or authority. The authors explore these elements in great detail, offering a timely and helpful update on this common gastrointestinal complaint. An abnormal condition of a part, organ, or system of an organism resulting from various causes, such as infection, inflammation, environmental factors, or genetic defect, and characterized by an identifiable group of signs, symptoms, or both. Nongastric malt lymphoma, secondline or subsequent therapy for refractory or progressive disease 4.
Ncis dictionary of cancer terms provides easytounderstand definitions for words and phrases related to cancer and medicine. Primary refractory refers to never achieving a complete remission cr from any therapy and also not being in partial remission pr at the time of the last evaluation prior to hsct. Refractory disease definition of refractory disease by. The term high temperatures is somewhat indefinite but usually means above about 1830f c, or temperatures at which, because of melting or oxidation, the common metals cannot be used. The main ocular manifestation is a whitish area in the central retina with a cherry. One of a number of ceramic materials for use in hightemperature structures or equipment. A disease is a particular abnormal condition that negatively affects the structure or function of. Refractory meaning best 17 definitions of refractory. Over twelve hours she developed refractory shock despite aggressive volume resuscitation and vasopressor use. The authors experience indicates that some clinical patterns of disease will benefit to be treated as refractory since the clinical presentation, for instance the antisrp autoantibodies seropositive adults patients who have a 5 year survival in less than 20% 16. High risk multiple myeloma is the last step in the progression of risk in multiple myeloma.
People with aids get many infections, often from diseases that dont affect people with healthy immune systems. Mar 31, 2021 refractory comparative more refractory, superlative most refractory obstinate and unruly. Pdf budesonide in the treatment of refractory celiac. Refractory definition of refractory by oxford dictionary. Refractory functional dyspepsia and nonerosive reflux disease tim elliott fracp andterry wong ma, md, frcp our series on prescribing challenges focuses on areas of therapeutics that can present a particular challenge in general practice. While biologic disease modifying antirheumatic drugs bdmards have transformed outcomes of people with rheumatoid arthritis ra, a proportion of patients are refractory to multiple bdmards. Refractory synonyms, refractory antonyms merriamwebster. The dictionary definition of refractory is resistant to treatment or cure. Many registries or countrywide data reports are unable to provide detailed primary and subsequent management.
Using this dictionary you can find almost all the disease definition. Pathogenesis refractory gout is considered an uncommon problem, but it remains a persistent challenge, and patients with this condition can have functional impairment and sharply reduced quality of life. To evaluate the efficacy of the combination of polatuzumab vedotin plus bendamustinerituximab br in relapsed refractory rr diffuse large bcell lymphoma dlbcl as measured by the positron emission tomography petdefined complete response cr rate using modified lugano response criteria at the time of primary response assessment 3 weeks after cycle 3 day 1 or. Mean age at the start of budesonide therapy was 56 yr, and all patients except 5 had celiac disease for at least 6 months duration range 1249 months. Refractory disease a refractory disease is a disease that resists treatment, especially an individual case that resists treatment more than is normal for the specific disease in question.
This is a stage in some diseases before the symptoms are first noted. Definition of refractory nci dictionary of cancer terms national. Refractory celiac disease is defined as symptoms and small intestinal inflammation that persist after one year on a strict glutenfree diet. A refractory material or refractory is a material that is resistant to decomposition by heat, pressure, or chemical attack, and retains strength and form at high temperatures.
In this report, we describe a case of intractable peptic ulcer disease that progressed to gastric outlet obstruction despite maximal medical therapy. To address the refractory disease definition some key questions must be answered. Refractory definition in the cambridge english dictionary. This, in turn, renders cells refractory to subsequent infection by the same or other viruses that use the cd4 receptor for entry. However, in some patients, ppi therapy and lifestyle changes are inadequate to control symptoms. Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray. The challenges in managing a case of refractory and. Refractory disease article about refractory disease by. A time travellers perspective gastroenterology 2009 6. An example of someone who is refractory is a person who refuses to listen to the rules. We describe a fulminant episode in a patient known to have the condition. Testing for refractory gastroesophageal reflux disease.
Millerkeane encyclopedia and dictionary of medicine, nursing, and allied. Esophagitis on endoscopy is a highly specific sign for gerd. This is very good application for finding the disease information. Definition gerd can be subdivided into erosive reflux disease or nonerosive reflux disease nerd based on endoscopic findings. Effect of nonsurgical periodontal treatment on the subgingival microbiota of patients with chronic kidney disease.
It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. Refractory gout management national kidney foundation. Budesonide in the treatment of refractory celiac disease. Refractory sprue or refractory coeliac disease rcd is defined by. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Both gout and refractory gout are very painful, but refractory gout more often leads to serious problems like permanent joint damage and trouble with moving and walking. Refractory article about refractory by the free dictionary.
Feb 27, 2019 a refractive disorder is an ocular condition caused by changes in the shape of the eye, which prevents light from being focused sharply on the retina, creating unclear images. Refractories are polycrystalline, polyphase, inorganic, nonmetallic, porous, and heterogeneous. Refractory definition of refractory by oxford dictionary on. This medical disease hand book can act as a clinical advisor for self diagnosis and can also be used to look up symptoms, diseases and treatment. Campieri department of internal medicine and gastroenterology, university of bologna, italy summary refractoriness to conventional therapy is a common and intriguing problem in crohns disease patients. Pdf what is the meaning of treatment resistantrefractory major. The american heritage medical dictionary copyright 2007, 2004 by houghton mifflin company. Rituximab for steroidrefractory chronic graftversushost.
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